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Leroid 25 | 1 Strip
Leroid contains synthetic Levothyroxine (T4), chemically identical to the natural thyroid hormone produced by the thyroid gland.
- Conversion: ~30% of T4 is converted to the active form Triiodothyronine (T3) in peripheral tissues.
- Binding: Most T4 is bound to Thyroxine Binding Globulin (TBG), prolonging half-life (6–7 days).
- Shortened half-life in hyperthyroidism (3–4 days)
- Prolonged half-life in hypothyroidism (9–10 days)
- Metabolism: Mainly in the liver via glucuronidation and sulfation; excreted in urine with enterohepatic recirculation.
- Therapeutic benefit: Once-daily dosing maintains stable T3 levels after dosage optimization.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Replacement therapy in hypothyroidism of any cause (primary, secondary, tertiary), except transient hypothyroidism during recovery from subacute thyroiditis.
TSH suppression in:
- Benign goitres and thyroid nodules
- Post-surgical or post-radiotherapy management of thyroid cancer
- Prevention of goitre from goitrogenic drugs (e.g., Lithium).
- Diagnostic aid in thyroid suppression tests.
(Use only under the supervision of a registered physician)
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects (usually from overdosage → hyperthyroidism symptoms)
General: Fatigue, weight loss, heat intolerance, sweating, fever.
CNS: Headache, insomnia, anxiety, irritability, hyperactivity.
Musculoskeletal: Tremors, muscle weakness.
Cardiovascular: Palpitations, tachycardia, arrhythmias, hypertension.
Respiratory: Dyspnea.
GI: Diarrhea, vomiting, abdominal cramps.
Skin: Hair loss, flushing.
✔️ Dosage & Administration
Adults
Initial: 25–50 mcg/day; increase by 12.5–25 mcg every 6–8 weeks until euthyroid and TSH normalized.
Severe hypothyroidism: Start at 12.5–25 mcg/day; increase by 25 mcg every 2–4 weeks with clinical/lab monitoring.
Secondary/Tertiary hypothyroidism: Adjust until free T4 is in the upper half of normal range.
Elderly or cardiac disease: ~1.7 mcg/kg/day, starting lower and titrating slowly.
Pediatric
Newborns: 10–15 mcg/kg/day; lower initial dose in cardiac risk infants, increase in 4–6 weeks as needed.
If serum T4 < 5 mcg/dL: start at 50 mcg/day.
Infants/Children (chronic/severe hypothyroidism): Start 25 mcg/day; increase every 2–4 weeks until target reached.
Weight-based dosing:
0–3 months: 10–15 mcg/kg/day
3–6 months: 8–10 mcg/kg/day
6–12 months: 6–8 mcg/kg/day
1–5 years: 5–6 mcg/kg/day
6–12 years: 4–5 mcg/kg/day
12 years, growth/puberty incomplete: 2–3 mcg/kg/day
Growth/puberty complete: 1.7 mcg/kg/day
✔️ Drug Interactions
Tricyclic/tetracyclic antidepressants: ↑ therapeutic/toxic effects; risk of arrhythmia & CNS stimulation.
Sertraline: May ↑ Leroid requirements.
Antidiabetics/insulin: May require ↑ doses; monitor glucose control.
Digitalis glycosides: ↓ serum levels and therapeutic effect after achieving euthyroid state.
✔️ Contraindications
- Untreated thyrotoxicosis
- Acute myocardial infarction
- Uncorrected adrenal insufficiency
✔️ Pregnancy & Lactation
Category A: Safe if dose adjusted; requirements may increase during pregnancy.
Minimal excretion in breast milk; adequate replacement needed for normal lactation.
✔️ Precautions
Adrenal insufficiency must be corrected before starting therapy.
Start low and go slow in elderly/cardiac patients to avoid arrhythmia or angina.
Adjust dose with major body weight changes.
Monitor TSH (primary hypothyroidism) or free T4 (central hypothyroidism).
✔️ Storage:
Store below 30°C, in a dry place, protected from light. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
